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KMID : 1123920200340040184
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Korean Journal of Oriental Physiology and Pathology
2020 Volume.34 No. 4 p.184 ~ p.190
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Systemic Analysis of Antibacterial and Pharmacological Functions of Scutellariae Radix
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Kim Hyo-Jin
Bak Se-Rim
Ha Hee-Jung
Kim Youn-Sook
Lee Boo-Kyun
An Won-Gun
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Abstract
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This study was performed to find antibacterial substances contained in Scutellariae Radix (SR) using a systems pharmacological analysis method and to establish an effective strategy for the prevention and treatment of infectious diseases. Analysis of the main active ingredients of SR was performed using Traditional Chinese Medicine Systems Pharmacology (TCMSP) Database and Analysis Platform. 36 active compounds were screened by the parameter values of Drug-Likeness (DL), Oral Bioavailability (OB), and Caco-2 permeability (Caco-2), which were based on the drug absorption, distribution, metabolism, and excretion indicators. The UniProt database was used to obtain information on 159 genes associated with active compounds. The main active compounds with antibacterial effects were wogonin, β-sitosterol, baicalein, acacetin and oroxylin-A. Target proteins associated with the antibacterial action were chemokine ligand 2, interleukin-6, tumor necrosis factor, caspase-8,9 and mitogen-activated protein kinase 14. In the future, systems pharmacological analysis of traditional medicine will be able to make it easy to find the important mechanism of action of active substances present in natural medicines and to optimize the efficacy of medicinal effects for combinations of major ingredients to help treat certain diseases.
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KEYWORD
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Scutellariae Radix, Antibacterial action, Gene ontology analysis, Systems pharmacological analysis
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